CARDENOLIDE GLYCOSIDES FROM Streptocaulon tomentosum WIGHT & ARNOTT (Nrif;p*HkeD) (ASCLEPIADACEAE) in MYANMAR
Abstract
- This paper describes the isolation and comparative studies on NMR spectra of cardenolide glycosides from Streptocaulon tomentosum Wight & Arnott (Asclepiadaceae). Nine cardenolides were isolated from the roots of Streptocaulon tomentosum. by column chromatography and identified by NMR spectroscopy. They are 17α-H-periplogenin, 17α-H-periplogenin-β-D digitoxose,17α-H-periplogenin-β-D cymarose, 17α-H-periplogenin-β-glucosyl-(1-4)-2-O-acetyl-digitalose, 17β-H-periplogenin, 17β-H-periplogenin-β-D digitoxose, 17β-H-periplogenin-β-D cymarose, 17α -H-digitoxigenin, and 17 α-H-digitoxigenin-β-D-digitoxoside. Comparative studies on NMR spectra of cardenolide glycosides were carried out. Six cardenolides isolated from Streptocaulon tomentosum were tested for their antiproliferative activity in vitro against MCF-7 (human breast cancer cell line) and L 929 (mouse fibroblast cell line). Among these six cardenolides, 17-H-periplogenin-3-O--D-digitoxoside and 17-H-periplogenin-3-O--D-cymaroside exhibit significant antiproliferative activity (IC50 values, < 1M) against MCF-7. Four cardenolides were examined for their cellular viability in the tumor cell and U 937 (human leukemic cell line) at concentrations 100 M, 10 M, and 1 M. All these four cardenolides show the induction of apoptosis at 100 M and 10 M in both cell lines.
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Year
- 2020
Author
-
Myint Myint Khine
Subject
- Chemistry
Publisher
- Myanmar Academy of Arts and Science (MAAS)