Abstract

• The present research focused on the investigation of antihyperglycemic activities of two crude extracts (70 % ethanol and water) and isolated organic compounds from bark of Mimusops elengi Roxb. (Kha-yay) by using adrenaline induced hyperglycemic rats. The optimum antihyperglycemic activities of two extracts showed 70 % ethanol extract (30.11 % reduction, p < 0.01, 1 h and 35.25 % reduction, p < 0.01, 2 h) and watery extract (19.94 % reduction, p < 0.01, 1 h and 21.61 % reduction, p < 0.01, 2 h) after treating with 2 g/kg body weight dose. Lupeol (0.0037 %, m.p- 215-217 °C) and spinasterol (0.0048 %, m.p- 167-169 °C) were isolated from pet-ether soluble portion of 70 % ethanol crude extract by column chromatographic method using pet-ether and ethyl acetate with increasing polarity ratio as eluent. Both compounds were identified by modern spectroscopic methods (UV, FT IR and 1H NMR) and confirmed by comparison with the data reported in literature. Reduction percent of blood glucose levels of lupeol and spinasterol with a dosage of 2 mg/kg body weight showed 19.44 % (p < 0.01) and 22.01 % (p < 0.01) at 2 h respectively.