Abstract

• The modified chitosan composite membranes (CASG-1 to CASG-4) were prepared with various ratios of chitosan, alginate, starch and glycerol by using casting and autoclaving methods. These membranes have smooth surfaces, highly transparent and pale yellow colour. The mechanical properties such as tensile strength, elongation at break and tear strength of these prepared membranes were determined. Based on the mechanical properties of the prepared composite membranes CASG2 was chosen for biomedical applications. The antimicrobial activities of prepared membranes were tested by agar well diffusion method. The skin irritation test was conducted by Draize’s method. The selected composite membranes (CASG-2) indicated that there is no irritation potential in albino rabbit skin. The selected composite membrane (CASG-2) was used to test in burn wound healing compared with standard sufre tulle drug. It was found that CASG-2 composite membrane was better than standard drug, sufre tulle for burn wound healing.