Abstract

• In this research work the stem of Dracaena angustifolia (Medik.) Roxb., Myanmar named Nant thar ku was selected for determination of antimicrobial, hypoglycemic and antioxidant activities. The stem of the selected plant was collected from Loikaw Township, Kayah State, in January, 2019. The aim of this research is to investigate the stem of Dracaena angustifolia (Medik.) Roxb. chemically and pharmaceutically. Preliminary phytochemical tests were performed by test tube method which gave positive for flavonoid, alkaloid, phenolic compound, polyphenol, glycoside, saponin, terpene, reducing sugar and tannin compounds. Antimicrobial activity of various solvent (n-hexane, ethyl acetate, acetone, ethanol, methanol) extracts was determined by agar well diffusion method and tested on six microorganisms such as Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus pumilus, Candida albicans and Escherichia coli. Ethanol, acetone and ethyl acetate extracts responded high activity on all tested organisms. Moreover, a potent hypoglycemic activity of the stem of this plant was examined by adrenaline induced diabetic mice model method. Glibenclamide was used as standard drug. This plant showed remarkable inhibitory activity. Antioxidant activity of the stem of selected plant was measured by DPPH (2,2-diphenyl-1-picrylhydrazyl-hydrate) assay method. IC50 value of selected plant was 3.17g/mL by comparing with standard ascorbic acid 0.90g/mL.