Abstract

• In this research work, one of the Myanmar indigenous medicinal plants, (Roxb.) Bedd. (thayet-thamon) was chosen for chemical analysis and pharmacological investigation of the stem bark. The acute toxicity test of 95 % ethanol extract of the stem bark of  was carried out in this study. The ethyl acetate extract was chromatographed by various chromatographic techniques to give pale yellow powder of pure compound (MML-1) and brown oily form of pure compound (MML-2). The antimicrobial activities of three different solvent extracts of crude sample and pure compounds (MML-1) and (MML-2) were tested by agar well diffusion method on six selected organisms;  and . Then, the antioxidant activity of ethanol crude extract and pure compounds (MML-1) and (MML-2) was evaluated by using DPPH radical scavenging assay. The molecular structures and conformational analyses of compounds (MML-1) and (MML-2) were determined by high resolution spectrometric techniques such as 1HNMR, 13CNMR, DEPT, DF-COSY, HMC, HMBC, EI MS spectral data and molecular modeling. The pure compounds (MML-1) and (MML-2) possess the types of flavonoid and lignan compounds