Abstract

• In this research paper, Corallodiscus lanuginosus (Wall. ex R.Br.)Burttwhich is one of the Myanmar indigenous medicinal plants known as Pan ma o` was selected for the study on the cytotoxicity and antioxidant activity. The cytotoxicity of the ethanol extract of the selected sample was more toxic to brine shrimp than the water extract. The LD50 values of ethanol and water extracts were 380μg/mL and 423μg/mL, respectively. On the other hand, the EtOH and water extracts were cytotoxic to brine shrimp up to maximum dose of 1000 μg/mL. The LD50 values of standard K2Cr2O7 and caffeine are 265 μg/mL and >1000 μg/mL, respectively. In addition, the larger radical scavenging activity to scavenge DPPH radical was observed in ethanol extract, which inhibited 50% of free radicals at the concentration (IC50) of 7.10 μg/mL than the water extract which inhibited 50% of free radicals at the concentration (IC50) of 11.13 μg/mL. Moreover, antimicrobial activities of the isolated porphyrin derivative compound were examined by using agar well diffusion method. The ethyl acetate extract of this porphyrin derivative compound responds high activities on Bacillus subtilis, Pseudomonas aeruginosa, Bacillus pumilus, Candida albicans and Escherichia coli.