Abstract

• Three coumarin compounds (1), (2), (3) and two alkaloid compounds (4) and (5) were isolated from the stem bark of Aegle marmelos, collected from Sagaing Region, Myanmar. The structures of these compounds were elucidated mainly by extensive spectroscopic analysis (1D and 2D NMR). The isolated compounds were screened for free radical scavenging activity using DPPH radical-scavenging assay. In addition, compounds (1-5) were evaluated in vitro for their cytotoxic activity against Hela cells. It was observed that pure compounds (1), (2), (3)(EC50>100 μM) exhibited lowerantioxidant activity than ascrobic acid(EC50 27.5 μM). The compound (4) (IC50 55 μM) exhibited low cytotoxic activity against Hela cell lines while compounds (1) and (5) displayed very weak cytotoxic activity with IC50 value > 100 μM.