Abstract

• s such as antioxidant, cytotoxic and antitumor activities on some crude extracts from locally cultivated Morinda citrifolia L. fruits (Y-yo) and Catharanthus roseus L. whole plant (Thin-baw-ma-nyoe). The antioxidant activity of ethanol and watery extracts evaluated by DPPH free radical scavenging assay showed that IC50 values of EtOH extract (4.395 mg/mL) and watery extract (8.878 mg/mL) from C. roseus were repsectively higher than those of EtOH extract (9.347 mg/mL) and watery extract (8.484 mg/mL) from M. citrifolia. The ethanol and watery extracts of both plant samples did not exhibit the cytotoxic effect determined by using brine shrimp cytotoxicity bioassay method. Antitumor activity screening determined by potato crown gall test revealed that ethanol and watery extracts of M. citrifolia and C. roseus can inhibit tumor growth. Tumor inhibition was significantly observed in the concentration of 0.2 g /mL for each extract.