Abstract

• Flemingia strobilifera (L.) R. Br. is medicinally important plant which belongs to the family Fabaceae. In this study, the evaluation on wound healing properties of 70% ethanolic root extract of Flemingia strobilifera (L.) R. Br. have been conducted in albino rat model. Male albino rats were divided into 3 groups contains 3 replicates each and anesthesia was administered by an intramuscular injection of xylazine and ketamine. The back side skin of the rats were shaved and an excision of 1 cm diameter on the shaved skin were prepared. In this experiment, group 1 was treated with ethanolic root extract, group 2 by standard treatment (Tetracycline ointment) and group 3 as the control. The rate of epithelialization and complete wound closure was daily recorded. A better healing pattern was observed in rats treated with ethanolic root extract and standard treatment (Tetracycline ointment) compared with the untreated control. The epithelialization period of the group 1 and 2 were much shorter than the group 3. Specimens of healed skin at a thickness of 5μ from each rat were taken at the 20th day of treatment and were fixed in 10% buffered formalin solution for histological studies. These skins were stained with hematoxylin and eosin (H & E) and assessed for histological changes. 70% ethanolic root extract of Flemingia strobilifera (L.) R. Br. group was well developed granulation tissues in all layers of skin. According to the results of this experiment, it may be concluded that 70% ethanolic root extract of Flemingia strobilifera (L.) R. Br. has the prospective outcome as a new therapeutic agent for wound healing.