MACROLIDE ANTIBIOTICS AND INDOLE ALKALOID PRODUCED FROM MARINE AND TERRESTRIAL BACTERIA
Abstract
- Chemical investigation of terrestrial bacteria Bacillus subtilis M 8 and marine-derived Streptomyces sp. B 8406 led to the identification of macrolide antibiotics, namely, macrolactin F (1) and borrelidin (3) respectively. Additionally, the strains delivered the precursor of indole alkaloid, tryptophan (2) and indole alkaloid, 6-prenyltryptophol (4) respectively. The structures of these metabolites were elucidated based on 1D and 2D NMR experiments and mass studies. Macrolactin F (1) showed weak antibacterial properties. Borrelidin (3) showed high activity against Escherichia coli, Candida albicans and Mucor miehei (Tü 284) by causing inhibition zones of 25, 30 and 30 mm, at 40 g/ disk; it showed medium activity against Staphylococcus aureus, Streptomyces viridochromogenes (Tü 57) and weak activity against Bacillus subtilis. It was also found to have an activity against Artemia salina of 93 %. Moreover, biogenesis of borrelidin (3) was discussed.
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Year
- 2020
Author
-
Hnin Yu Win
Subject
- Chemistry
Publisher
- Myanmar Academy of Arts and Science (MAAS)