Abstract

• One of the medicinal plants, namely Muntingia calabura L. (Hnget Thagya), belonging to the family Muntingiaceae was selected for pharmacological activity. Glucose uptake capacity by yeast cells of ethyl acetate and ethanol extracts were evaluated by using yeast cell model. Ethyl acetate extract showed the highest efficiency (84.99 ± 0.37) % and ethanol extract also showed the highest efficiency (64.95 ± 1.47) % at 25 mM of glucose solution. Thus, the ethyl acetate extract is more effective than ethanol extract. It was also found that the percent of glucose uptake by yeast cells increased at different glucose concentrations in both extracts. Furthermore, the antihyperglycemic activity of ethyl acetate extract was determined by using adrenaline induced mice model. Ethyl acetate extract showed decrease in blood glucose levels for test animals within 90 minutes to 225 minutes. Moreover, structural elucidation of organic compound from the extract such as β-sitosterol, gallic acid and catechin were performed by using advanced spectroscopic methods such as FT IR, 1 H NMR (600 MHz),13 C NMR (150 MHz), DQF-COSY, HSQC and HMBC spectral data respectively.