Abstract

• The root of Cinnamomum bejolghota (Buch.-Ham.) traditional medicine uses Sweet, also known as Na-lin-gyaw, is extensively utilized in traditional medicine to treat various ailments. This study aimed to investigate some phytochemical constituents and assess biological activities, including antioxidant, antimicrobial, and cytotoxic properties. The antioxidant activity screening revealed IC50 values of 14.77 μg/mL for the ethanol extract and 59.57 μg/mL for the aqueous extract. The antimicrobial activity of different crude extracts (petroleum ether, ethyl acetate, ethanol, and water) was evaluated against eight strains of microorganisms using the agar well diffusion method, with the ethanol extract demonstrating significant antimicrobial efficacy. Additionally, the cytotoxicity of both the aqueous and ethanol extracts of C. bejolghota was assessed using the brine shrimp cytotoxicity bioassay, revealing that the ethanol extract exhibited greater cytotoxicity than the aqueous extract. The antioxidant, antimicrobial, and cytotoxic activities observed in the extracts may indicate potential therapeutic applications, including infections caused by microorganisms, oxidative stress related conditions, and certain types of cancer.