Research List

No.	Researcher	Title	Abstract	Year
2311	Aung Than Htwe, Maung Htwe, May Myat Noe, Khine Phyu Phyu Thant	PREPARATION, CHARACTERIZATION AND ANTIMICROBIAL PROPERTIES OF CHITIN BASED POLYVINYL ALCOHOL BLENDED FILMS	In this research, high strength chitin (CT) - based polyvinyl alcohol (PVA) blended films were prepared by adding different amounts of PVA to chitin dissolved in an aqueous formic acid solution and then by a solvent evaporating technique at room temperature. All prepared blended films have smooth surfaces, are highly transparent, and pale yellow in colour. The physical parameters, the mechanical properties, the degree of swelling and water uptake the prepared blended films were determined. The swelling and water uptake of the blended membrane have a higher degree of hydration, as measured by swelling and water uptake, which can be altered by varying the weight percent of PVA in the membrane matrix. From FT IR analysis, the characteristic absorption peaks of the CT-based PVA blended film clearly showed that the two polymers were blended. A SEM micrograph of CT-based PVA blended films showed homogeneous and amorphous phases. The XRD patterns of the CT-based PVA blended films also exhibited crystallinity. According to TG-DTA analysis, the thermal stability of the CT-based PVA blended were found to decrease. All of the prepared CT-based PVA blended films showed effective antimicrobial activities. The prepared CTbased PVA blended films exhibited excellent biocompatibility and safety in the environment and may also be intended for use in burning dressings and packaging materials.	2024
2312	Kay Khine Win Swe, Prema, Zin Thu Khine, Ni Ni Than	INVESTIGATION OF SOME BIOACTIVITIES AND PHYTOCONSTITUENTS FROM THE PEELS OF DIMOCARPUS LONGAN LOUR. (LONGAN)	The aim of the present work is to investigate the total phenolic contents, antioxidant, cytotoxic, and anti-arthritic activities, and phytoconstituents of Dimocarpus longan Lour. (Longan) peel (LGP). The total phenolic content of ethanol and watery extracts from LGP was determined by the FolinCiocalteu Reagent (FCR) method. Total phenolic content was found to be the highest in ethanol extract (176.12 � 0.15) ?g/mL. The in vitro antioxidant activity of ethanol and watery extracts of LGP was assessed by the DPPH free radical scavenging assay. The IC50 values were found to be 70.52 ?g/mL for the watery extract and 8.77 ?g/mL for the ethanol extract of LGP. The cytotoxicity of the watery and ethanol extracts was evaluated by a brine shrimp lethality bioassay. From these results, the LD50 values of watery and ethanol extracts were found to be non- toxic at the 1000 ?g/mL concentration. The anti-arthritic activity of watery and ethanol extracts screened by the egg albumin method. According to the data, the watery extract (IC50 = 97.77 ?g/mL) is more potent than standard diclofenac sodium (IC50 = 57.57 ?g/mL) in anti-arthritic activity. By silica gel column chromatographic separation technique, two steroids, one terpenoid and a steroidal carboxylic acid were isolated from petroleum ether extract of LGP and characterized by physico-chemical properties and the FT IR spectroscopic method.	2024
2313	Prema, Hnin Htet Wai Nyunt, Yi Yi Win, Daw Hla Ngwe, Hiroyuki Morita	VIRAL PROTEIN R INHIBITORS FROM SOME MEDICINAL PLANTS COLLECTED IN MYANMAR	The aim of the study is to identity a viral protein R (Vpr) inhibitor from the bioactive selected medicinal plants collected in Myanmar. Their methanol and chloroform extracts were tested separately for their inhibitory effect on Vpr activities on the TREx-HeLa-Vpr cells. The chloroform extracts of P. javanica wood, G. sherwoodiana rhizomes, and K. candida roots and rhizomes showed the most potent anti-Vpr activities with cell proliferation percentages of 178%, 160%, and 160% at 10 �g/mL, respectively. Then, the thirty-nine compounds were isolated from these three bioactive samples, identified by UV, FT IR, NMR, HR-ESI-MS, and CD. Five new quassinoids (1-5), together with ten known compounds (6-15) were isolated from the active chloroform extract of the P. javanica wood. Isolated quassinoids 1-4, 6-9, and 10 displayed potent anti-Vpr activity, with the cell proliferation rate ranging from 148% to 181%, at the 5 �M concentration. Then, two new homodrimane type sesquiterpenoids (16 and 17), a new 16-norlabdane diterpenoid (18), two new naturally occurring compounds (19 and 20), together with eleven known compounds (21-31) were isolated from the chloroform extract of the G. sherwoodiana rhizomes. The isolated compounds 16, 18, 19, 23, 24, 27, and 29 showed moderate anti-Vpr activities at a concentration of 10 �M. In addition, three new compounds (32-34), together with five known compounds (35-39) were isolated from the chloroform extract of the K. candida roots and rhizomes. All of the isolated compounds showed moderate anti-Vpr activities on the TREx-HeLa-Vpr cells. Among the isolated compounds, 32 and 34-38 possessed higher anti-Vpr activity than 33 and 39.	2024
2314	Thet Thet Mon, Prema, Khin Chaw Win, Ni Ni Than	COMPARATIVE STUDIES ON PHYTOCHEMICAL CONSTITUENTS AND SOME BIOLOGICAL ACTIVITIES OF THE SEEDS, FRUITS, LEAVES, AND BARK OF ZIZIPHUS MAURITIANA LAM. (ZEE)	The aim of this research is to isolate bioactive compounds and to investigate some biological activities, such as antioxidant, ?-amylase and antimicrobial activity, of the fruits, seeds, bark and leaves of Ziziphus mauritiana Lam. (Zee). According to the phytochemical tests, Zee bark and leaves have more secondary metabolites than other. By thin layer and silica gel column chromatographic methods, lupeol was isolated from the ethyl acetate extract of the seeds and identified by the nuclear magnetic resonance (NMR) spectroscopic method. The antioxidant activity of bark of ethanol extract (IC50 = 2.51 ?g/mL) and watery extract (IC50 = 3.30 ?g/mL) was found, and Zee leaves of ethanol extract (IC50 = 3.10 ?g/mL) and watery extract (IC50 = 2.11 ?g/mL) were detected. In ?-amylase activity, the percent inhibition of ?-amylase activity of ethanol extracts of fruits, seeds, bark and leaves has good activity, but water extracts have mild activity. According to antimicrobial activity, the ethanol extracts of all four portions have good activity.	2024
2315	Sann Myint Oo, Thinn Myat Nwe, Myint Myint Sein	STRUCTURE ELUCIDATION OF AN ISOLATED COMPOUND FROM THE HENLIN HOT SPRING DERIVED THERMOPHILIC BACTERIAL STRAIN AND ANTIBACTERIAL ACTIVITY	The thermophilic bacterial strain No. 21 which was obtained from the Department of Biotechnology, Mandalay Technical University, showed antagonistic activity against S. aureus (MRSA). Ethyl acetate crude extract was prepared from the strain fermentation broth. A pure Organic compound (SMOo) was isolated as a colourless oily form (250 mg) from ethyl acetate extract by chromatographic separation methods. The chemical structure of the isolated compound was identified by using modern spectroscopic techniques such as FT IR, 1H NMR, COSY, 13C NMR, HMQC, DEPT, HMBC and EI-MS. In addition, the antibacterial activity of the isolated compound was investigated by the agar well diffusion method and the isolated compound showed significant inhibitory activity on S. aureus (MRSA).	2024
2316	Tin Zar Ni Tun, Myat Kyaw Thu, Wai Lin Oo	STUDY ON KINETIC PROPERTIES OF CATALASE ISOLATED FROM CORIANDRUM SATIVUM L. LEAVES	Isolation and purification of catalase enzyme from Coriandrum sativum L. leaves were performed by ammonium sulphate precipitation followed by dialysis and gel filtration chromatography on Sephadex G-100. The catalase activity of the final purification steps was measured by following the dismutation of H2O2 spectrophotometrically using an extinction coefficient for H2O2 at 439 nm of 0.0113 mM-1 cm-1 . The effect of substrate concentration and enzyme concentration on the catalase-catalyzed reaction was studied. The Km value was calculated to be 5.1420 � 10-3 M H2O2, and the Vmax value was found to be 0.1308 M min-1 using the plot of Lineweaver-Burk. The activation energy (Ea) of the catalase-catalyzed reaction was calculated to be 2.978 kcal mol-1 . The reaction order (n) of the catalase-catalyzed reaction was found to be the first-order reaction. The catalase activity decreased with each hour of incubation in buffers with different pH values and temperatures. After 3 h of incubation at 40 �C, the catalase activity was almost completely lost.	2024
2317	Phyu Phyu Myint and Myat Kyaw Thu	PHOTOCATALYTIC EFFECTS OF ZINC OXIDE NANOPARTICLES ON DEGRADATION OF ROSE BENGAL DYE	ZnO nanoparticles were synthesized by using the co-precipitation method with the precursors Zn (CH3COO)2, 2H2O, and NaOH. Three different lighting environments-darkness, daylight, and sunlight�were used in this study to examine how ZnO nanoparticles affected the photocatalytic degradation of rose bengal dye solutions. The effects of contact time, dye concentration, and catalytic dosage were studied to better understand the photocatalytic process. The photocatalytic activities of ZnO nanoparticles were investigated at three pH values: 4, 7, and 10. The optimum degradation was found to be 96.483% after 2 h of contact time at a pH of 7 under sunlight. The optimum concentration of the dye solution was determined to be 10 ppm, and the photodegradation percent under sunlight at a pH of 7 was found to be 96.003%. The optimal ZnO nanoparticle dosage was 0.30 g, and the percentage of colour deterioration was calculated to be 98.113% at a pH of 7. The photocatalytic activity of ZnO was highest at a pH of 7, compared to pHs of 4 and 10	2024
2318	Naw Yoon Eimzi Tun, Hnin Yu Wai	SYNTHESIS AND CHARACTERIZATION OF NANO ALUMINIUM OXIDE FROM WASTE ALUMINIUM CANS	The majority of the energy drinks are labelled as �canning� (in which aluminum sheet is commonly used). Can is a waste material that pollutes our environment. This research aims to take advantage of aluminium waste cans (Coca Cola) by using them as raw materials for preparing alumina (Al2O3) by the co-precipitation method. The synthesis of ?-Al2O3 from waste aluminium cans is presented in this study. The proposed technique was the precipitation of aluminum chloride with NaOH to produce aluminium hydroxide. The obtained Al (OH)3 was washed, crushed, and dried at 105 �C, and then it was converted to alumina by calcination using different calcination temperatures (500, 600, 700 and 800�C) for 2 h. The prepared aluminium oxide nanoparticles were characterized by EDXRF, FT IR, SEM and XRD techniques. The ?-Al2O3 phase was found in the sample calcined at 600 �C, according to XRD data. The methodology has the capability to produce nano-alumina powder; the average crystal size was 30.05� 51.49 nm. Furthermore, the SEM image of these samples revealed that the ?-Al2O3 phase had an irregular spherical shape. Thus, the use of waste aluminium can precursors simplifies the process, and the synthesized alumina is a valued added material.	2024
2319	Su Myat Htay, Ye Myint Aung, Yee Mun Than	OPTIMIZATION FOR COLOUR REMOVAL PROPERTY OF PREPARED REDUCED GRAPHENE OXIDE (rGO)	In this study, the modified Hummer process was used to synthesize graphene oxide (GO) from graphite powder. Later, GO was chemically reduced to form reduced graphene oxide (rGO) nanoparticles using hydrazine hydrate as the reducing agent. Techniques such as XRD, FT IR, UVvisible, SEM, and EDX were used to characterize the prepared rGO. Malachite green (MG), a cationic dye, was employed as a model dye contaminant to study the colour removal efficiency of rGO. In order to assess the optimal values of the important parameters, including the initial dye concentration, pH, contact time, and rGO dosage, batch adsorption tests were conducted. For the purpose of removing the colour of malachite green utilizing synthesized rGO, the optimum conditions were found to be 10 ppm of MG concentration, pH 4, 60 min of contact time, and 0.06 g of adsorbent dosage.	2024
2320	Nwe Mar Lin, Yee Mun Than, Myat Kyaw Thu	PREPARATION AND INVESTIGATION OF SOME PHYSICOCHEMICAL PARAMETERS IN ANABAS TESTUDINEUS (NGA PYAE MA) FISH SAUCE SUPPLEMENTED WITH PAPAIN ENZYME	In this study, the fish sauce was prepared using the papain enzyme from the mature green leaves of Carica papaya L. The papain enzyme was isolated using ammonium sulphate precipitation (20%�70%). Fish samples of Anabas testudineus (Nga Pyae Ma) from the local market in Maubin Township, Ayeyarwady Region, were obtained for this investigation. Fish sauces were produced both with and without the papain enzyme. This study revealed how the physicochemical characteristics of fish sauce containing papain changed during fermentation, including pH (6.2 -7.0), refractive index (1.375-1.386), specific gravity (1.174-1.178), sodium chloride (19.59-20.27 %), total nitrogen (1.34-1.93 %), protein (8.38-12.06 %), formal amino nitrogen (0.60-1.00 %), and degree of hydrolysis (44.78-51.81 %). When compared to those without papain enzyme, it was found that fish sauces containing papain enzyme produced the most favorable outcomes. These results show that the use of papain to speed up the production of fish sauce is important.	2024

Research Publications

Myanmar Academy of Art & Science List of Research